Axsome Therapeutics, Inc. (AXSM) Stock Analysis 2026

HealthcareBiotechnology

BriMind AI Score

Proprietary
65
Moderate
Price CAGR
35.6%
1Y Return
+12.0%
Analyst Upside
+93.3%
Rev Growth
45.5%

Score based on historical price CAGR, revenue growth, analyst upside, and valuation factors. Updated daily.

AI scores and price targets are for informational and educational purposes only. They do not constitute financial advice or a recommendation to buy or sell any security. Past performance is not indicative of future results. Always conduct your own research before making investment decisions. Full Disclaimer →

AXSM Revenue & Profitability Breakdown

This chart shows how AXSM's revenue flows through to profit. Each row deducts a layer of costs: first the direct cost of making products/services (Cost of Revenue), then operating expenses like marketing and R&D, then taxes. What remains at the bottom is net income — the actual profit shareholders own. High gross and net margins indicate a business with strong pricing power and efficiency.

Revenue
$776.6M
Cost of Revenue
-$52.5M
Gross Profit
$724.0M93.2% margin
Operating Expenses
-$724.0M
Operating Income
$0-23.4% margin
Tax & Other
-$191.6M
Net Income
-$-191.6M-24.7% margin
Gross Margin
93.2%
Operating Margin
-23.4%
Net Margin
-24.7%

Key Financial Metrics

Axsome Therapeutics, Inc. doesn't carry a meaningful trailing P/E right now, generates $-4.6M in free cash flow, runs a debt/equity ratio of 269.73, and converts shareholder equity into profit at a -245.1% return on equity. For context: P/E ratio measures how much you pay for $1 of earnings (lower = cheaper, but fast-growing companies command higher P/E); Free Cash Flow is the cash left after running the business; Debt/Equity shows how leveraged a company is; Return on Equity shows how efficiently it turns shareholder capital into profit.

Market Cap
$11.56B
P/E (Forward)
43.85
Price / Book
138.58
Revenue
$776.6M
Revenue Growth
45.5%
EPS (Trailing)
$-3.75
EPS (Forward)
$5.03
Gross Margin
93.2%
Operating Margin
-23.4%
Net Margin
-24.7%
Return on Equity
-245.1%
Return on Assets
-16.3%
Free Cash Flow
$-4.6M
Debt / Equity
269.73
Current Ratio
1.43
Quick Ratio
1.30
Beta
0.71
Dividend Yield
None
Payout Ratio
0.0%
Insider Ownership
15.1%
Inst. Ownership
74.6%
Short % Float
9.1%
Book Value / Share
$1.59

Wall Street Analyst Consensus

Wall Street analysts covering Axsome Therapeutics, Inc. currently haven't converged on a clear consensus rating, with a mean 12-month price target of $285.42. Analysts set these targets after researching a company's earnings, competitive position, and industry trends — Strong Buy / Buy means the majority expect meaningful upside, while Hold means fair value near the current price rather than a sell signal.

Mean Target$285.42

Intrinsic Value Estimates for AXSM

We use 1 valuation model to estimate AXSM's intrinsic value. Intrinsic value is what a stock is truly worth based on the company's fundamentals, independent of what the market prices it at today. If multiple models agree the stock is undervalued, that convergence is a stronger signal.

P/E Based (15× forward)
$75.51
Multiplies next year's estimated earnings per share by 15×. More forward-looking; useful for high-growth companies where current earnings understate potential.
Fair Value Range
$75.51 – $75.51
Average Estimate
$75.51

Intrinsic value estimates use simplified models (Graham, DCF, P/E) and conservative assumptions. They should be used as one input among many — not as sole buy/sell guidance. For advanced analysis, see the full platform.

Technical Price Signals

AXSM is currently in a mixed technical position. Moving averages smooth out day-to-day volatility to reveal the underlying trend — a Golden Cross (50MA crosses above 200MA) is a classic bullish signal, a Death Cross is bearish, though both are lagging indicators that confirm trends rather than predict them.

50-Day MA
$221.40
200-Day MA
$196.05

Compare AXSM with Peers

JAZZ vs AXSMJazz Pharmaceuticals vs Axsome Therapeutics — Sleep & C

Further Reading

Research and guides that put AXSM’s numbers in context — how to read the filings behind them, and the frameworks we use to score them.

Market TheoryStock Market Seasonality: Monthly Returns, 'Sell in May,' and What History SaysMarket TheoryWe Backtested 929 Insider Cluster Buys — The Signal Everyone Trusts Loses to the S&P 500Fundamentals58% of Insider Selling Is Noise — How to Find the Part That MattersMarket TheoryThe Stock-Split Pop Is a Myth: What 39 Real Splits Actually Did

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Data sources: Financial metrics and market data sourced from company SEC filings, earnings releases, and investor relations disclosures. Price data, analyst consensus targets, and fundamental financials provided by financial market data providers. ETF data sourced from official fund prospectuses and index provider publications. AI scores and price targets are proprietary estimates — see our Methodology and Disclaimer for details.
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