When APMD insiders can sell

…of Contents No Sales of Similar Securities We, our executive officers and directors and our other existing security holders have agreed not to sell or transfer any common stock or securities convertible into, exchangeable for, exercisable for, or repayable with common stock (collectively, the Lock-Up Securities), for 180 days after the date of this prospectus without first obtaining the written consent of BofA Securities, Inc., Evercore Group, L.L.C. and Cantor Fitzgerald & Co. Specifically, we and these other persons have agreed, with certain limited exceptions, not to directly or indirectly: offer, pledge, sell or contract to sell any common stock; sell any option or contract to purchase any common stock; purchase any option or contract to sell any common stock; grant any option, right or warrant for the sale of any common stock; lend or otherwise dispose of or tra…

Rule 10b5-1 Trading Plans Following the closing of this offering, certain of our officers, directors and significant stockholders may adopt written plans, known as Rule 10b5-1 trading plans, in which they will contract with a broker to buy or sell shares of our common stock on a periodic basis to diversify their assets and investments. Under these 10b5-1 trading plans, a broker may execute trades pursuant to parameters established by the officer, director or stockholder when entering into the plan, without further direction from such officer, director or stockholder.

Sekhri serves on the boards of various charitable organizations, including the Advisory Council of the New York Philharmonic, and is Chairman of Young Concert Artists, Inc. He previously served on the board of directors of the Metropolitan Opera from 2018 to 2025. Mr. Sekhri received a B.S. from the University of Maryland and completed postgraduate studies in clinical anatomy and neuroscience at the University of Maryland. We believe that Mr. Sekhri is qualified to serve on our board of directors because of his extensive leadership experience in the biopharmaceutical industry.

…iatrists and chiropractors), to certain non-physician providers such as physician assistants and nurse practitioners, and to teaching hospitals, as well as ownership and investment interests held by physicians and their immediate family members. Federal price reporting laws require manufacturers to calculate and report complex pricing metrics to government programs, where such reported prices may be used in the calculation of reimbursement or discounts on approved products. Federal consumer protection and unfair competition laws broadly regulate marketplace activities and activities that potentially harm consumers. Analogous state a…

…a Convertible Note and collectively, the Convertible Notes), into an aggregate of 25,975,771 shares of common stock upon the closing of this offering, and excludes: 6,796,259 shares of our common stock issuable upon the exercise of options at a weighted-average exercise price of $3.85 per share as of March 31, 2026; 2,821,625 shares of our common stock issuable upon the exercise of options, granted after March 31, 2026, at a weighted-average exercise price of $8.15 per share; 100,163 shares of our common stock underlying warrants issued to HCRx Investments HoldCo, L.P., HCR Stafford Fund II, L.P. and HCR Potomac Fund II, L.P (collec…