When SCTX insiders can sell

The lock-up agreements pertaining to this offering will expire 180 days from the date of this prospectus. However, Leerink Partners LLC and Goldman Sachs & Co. LLC may, in their sole discretion, permit our officers, directors and other current stockholders who are subject to the contractual lock-up to sell shares prior to the expiration of the lock-up agreements. After the lock-up agreements expire, the shares of common stock subject to these lock-up agreements will be eligible for sale in the public market, unless held by our officers, directors and their affiliated entities, in which case such shares will be subject to volume limitations under Rule 144 under the Securities Act of 1933, as amended, or the Securities Act.

Rule 10b5-1 Plans Our directors, officers and key employees may adopt written plans, known as Rule 10b5-1 plans, in which they will contract with a broker to buy or sell shares of our common stock on a periodic basis. Under a Rule 10b5-1 plan, a broker executes trades under parameters established by the director or officer when entering into the plan, without further direction from the director or officer. The director or officer may amend or terminate a Rule 10b5-1 plan, subject to certain requirements.

…ors), certain other healthcare professionals (such as physician assistants and nurse practitioners), and teaching hospitals, as well as ownership and investment interests held by the physicians described above and their immediate family members, with the information made publicly available on a searchable website; analogous state and foreign laws and regulations, such as state anti-kickback and false claims laws, that may apply to sales or marketing arrangements and claims involving healthcare items or services reimbursed by non-governmental third-party payors, including private insurers; and certain state laws that require pharmace…

…nal shares of common stock that the underwriters have an option to purchase), for sale at the initial public offering price to certain of our directors, officers, employees and other persons associated with us through a directed share program. See "Underwriting—Directed Share Program" for additional information. The underwriters expect to deliver the shares of common stock to purchasers on or about July 27, 2026. Leerink Partners Goldman Sachs & Co. LLC Guggenheim Securities Wells Fargo Securities July 23, 2026 Table of Contents TABLE OF CONTENTS Page Prospectus Summary 1 The Offering 14 Summary Financial Data 17 Risk Factors 19 Spe…

…giving effect to (i) the Preferred Stock Conversion, (ii) the Warrant Conversion and (iii) the Note Conversion, each as defined and described below), and excludes: 1,180,162 shares of our common stock issuable upon the exercise of stock options to purchase shares of our common stock outstanding as of March 31, 2026 under our 2018 Stock Incentive Plan, or the 2018 Plan, at a weighted-average exercise price of $7.18 per share; 17,560 shares of our common stock issuable upon the exercise of stock options to purchase shares of our common stock granted after March 31, 2026 under our 2018 Plan, with a weighted-average exercise price of $…