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REGN
Regeneron Pharmaceuticals, Inc. · Healthcare
$768.58
+18.28% this month
VERSUS
⟷
COMPARE
BIIB
Biogen Inc. · Healthcare
$206.63
-0.88% this month
Scoreboard verdict
Across AI score, momentum, valuation, upside, operating margin
REGN
2
BIIB
3
Comparison scoreboard
BIIB LEADS 3/5AI Score
REGN ✓42.8
BIIB 28.7
1Y Return
REGN +34.86%
BIIB ✓+55.49%
Fwd P/E
REGN 12.78
BIIB ✓12.25
Target Up.
REGN +9.30%
BIIB ✓+15.47%
Op. Margin
REGN ✓33.11%
BIIB 25.06%
Metrics last refreshed: 8/6/2026
Quick take
REGN vs BIIB Stock Comparison: AI Score, Valuation, Performance and Upside
Regeneron and Biogen are both innovative biopharma companies with flagship products, but their risk profiles are sharply different. REGN's Dupixent is a proven, rapidly growing blockbuster with multiple expanding indications providing near-term earnings visibility. BIIB's Leqembi is a pioneering Alzheimer's drug but faces significant commercial challenges that have made its ramp much slower than anticipated.
Investors must choose between Regeneron's high-quality, high-multiple growth driven by Dupixent's proven commercial success versus Biogen's lower-multiple value proposition dependent on Leqembi proving it can overcome commercialization barriers at scale.
Live analysis · updated 8/6/2026
BIIB holds the edge across 3 of 5 key metrics in this comparison. BIIB leads on both 1-year return (+55.49%) and forward P/E quality (12.25x vs 12.78x for REGN), a relatively favorable combination of momentum and valuation. REGN leads on both revenue growth (16.70%) and operating margin (33.11%), suggesting a stronger fundamental setup on both dimensions. Analyst consensus implies meaningfully more upside for BIIB (+15.47%) than for REGN (+9.30%).
Normalized 1Y performance
REGN
BIIB
Recent returns
REGN
BIIB
Analyst price targets & sentiment
REGN · 23 analysts
STRONG BUYHOLDSTRONG SELL
Buy (1.7/5.0)
Price target range
analyst low$535.00
analyst high$950.00
analyst mean$833.54
current price$768.58
+9.3% upside to analyst mean
BIIB · 31 analysts
STRONG BUYHOLDSTRONG SELL
Buy (2.2/5.0)
Price target range
analyst low$115.00
analyst high$260.00
analyst mean$234.35
current price$206.63
+15.5% upside to analyst mean
Who should consider this stock?
REGN may suit investors who:
- →want high-quality biopharma growth anchored by Dupixent's expanding multi-indication platform
- →value proprietary antibody discovery technology providing durable pipeline optionality
- →prefer companies with strong balance sheets and consistent earnings growth
- →are comfortable with premium valuation for superior pipeline visibility
BIIB may suit investors who:
- →believe Leqembi's Alzheimer's market will overcome payer and access barriers over time
- →see deep-value potential in a neuroscience leader trading at a discount to intrinsic value
- →want exposure to a potential breakthrough Alzheimer's franchise at an early commercial stage
- →are comfortable with higher uncertainty and longer timelines for the thesis to play out
Performance & AI score
| Metric | REGN | BIIB |
|---|---|---|
| AI score | 42.8 | 28.7 |
| AI rank | #827 | #2349 |
| Latest close | $768.58 | $206.63 |
| 1M return | +18.28% | -0.88% |
| 6M return | -0.84% | +11.42% |
| 1Y return | +34.86% | +55.49% |
$10,000 invested — hypothetical growth (dividends reinvested)
How much would $10,000 be worth today if invested at the start of each period, with all dividends reinvested?
| Period | REGN | BIIB |
|---|---|---|
| 1Y ago | $13.85K (+38.5%) started 2025-08-06 | $15.98K (+59.8%) started 2025-08-06 |
| 5Y ago | $12.57K (+25.7%) started 2021-08-09 | $6.07K (-39.3%) started 2021-08-09 |
| 10Y ago | $18.33K (+83.3%) started 2016-08-08 | $6.59K (-34.1%) started 2016-08-08 |
Hypothetical — past performance does not guarantee future results.
Valuation & upside potential
| Metric | REGN | BIIB |
|---|---|---|
| Market cap | $78.52B | $29.99B |
| Trailing P/E | 18.87 | 36.11 |
| Forward P/E | 12.78 | 12.25 |
| Price/Sales | 3.78 | 1.99 |
| EV/Revenue | 4.56 | 3.69 |
| Analyst target | $833.54 | $234.35 |
| Target upside | +9.30% | +15.47% |
Growth, profitability & risk
| Metric | REGN | BIIB |
|---|---|---|
| Revenue growth | 16.70% | 3.40% |
| Earnings growth | -4.50% | -84.80% |
| EPS growth | -4.50% | -84.80% |
| FCF margin | +19.73% | +12.63% |
| Operating margin | 33.11% | 25.06% |
| Profit margin | 27.87% | 8.32% |
| ROIC proxy | 14.04% | 4.58% |
| Return on equity | 14.04% | 4.58% |
| Dividend yield | 0.49% | N/A |
| Beta | 0.24 | 0.16 |
| Debt/equity | 8.54 | 44.33 |
| Current ratio | 3.33 | 1.86 |
| Quick ratio | 2.63 | 0.94 |
Drawdown & downside risk
Lower drawdown and smaller single-period drops generally indicate a smoother ride, though they do not guarantee lower future risk.
1Y risk snapshot
REGN max drawdown26.05%
BIIB max drawdown14.34%
REGN max wkly drop12.87%
BIIB max wkly drop12.37%
5Y risk snapshot
REGN max drawdown59.69%
BIIB max drawdown67.59%
REGN max wkly drop20.21%
BIIB max wkly drop13.62%
10Y risk snapshot
REGN max drawdown59.69%
BIIB max drawdown72.66%
REGN max wkly drop20.21%
BIIB max wkly drop34.30%
Performance metrics by period
| Period | Metric | REGN | BIIB |
|---|---|---|---|
| 1Y | Growth | +38.45% | +59.76% |
| CAGR | +38.53% | +59.89% | |
| Sharpe ratio | 1.01 | 1.37 | |
| Max drawdown | 26.05% | 14.34% | |
| Max daily drop | 9.82% | 8.17% | |
| Max wkly drop | 12.87% | 12.37% | |
| 5Y | Growth | +25.53% | -39.26% |
| CAGR | +4.66% | -9.51% | |
| Sharpe ratio | 0.16 | -0.26 | |
| Max drawdown | 59.69% | 67.59% | |
| Max daily drop | 19.01% | 8.17% | |
| Max wkly drop | 20.21% | 13.62% | |
| 10Y | Growth | +83.05% | -34.12% |
| CAGR | +6.24% | -4.09% | |
| Sharpe ratio | 0.21 | -0.01 | |
| Max drawdown | 59.69% | 72.66% | |
| Max daily drop | 19.01% | 29.23% | |
| Max wkly drop | 20.21% | 34.30% |
Business comparison
| Category | REGN | BIIB |
|---|---|---|
| Company | Regeneron Pharmaceuticals, Inc. | Biogen Inc. |
| Sector | Healthcare | Healthcare |
| Industry | Biotechnology | Drug Manufacturers - General |
| Core business | Regeneron is a science-driven biopharmaceutical company with a technology platform (Veloci-Suite) that enables rapid antibody discovery. Its commercial portfolio is anchored by Dupixent (dupilumab) for atopic dermatitis and other Th2-driven inflammatory diseases, growing at 25%+ annually with multiple ongoing label expansions. Eylea (aflibercept) for eye diseases provides a second major revenue stream, though facing biosimilar competition from Eylea HD (its own successor product). REGN-EB3 for Ebola and odronextamab in lymphoma represent additional pipeline assets. | Biogen pioneered the treatment of multiple sclerosis and remains a leader in MS with drugs including Tecfidera (now generic), Tysabri, and Vumerity. Its Alzheimer's franchise — lecanemab (Leqembi, developed with Eisai) — represents the company's highest-stakes pipeline bet, as one of the first amyloid-clearing drugs to show clinical benefit. Biogen also has biosimilars revenue and a neuroscience portfolio including Skyclarys for Friedreich's ataxia. |
| Investor focus | Investors focus on Dupixent's expanding indications (COPD, prurigo nodularis, and others), the Eylea to Eylea HD transition success, and the depth of the broader pipeline beyond these two anchors. | Investors track Leqembi's commercial uptake (slowed by payer coverage and infusion logistics challenges), MS product revenue retention against generic competition, and whether the broader neuroscience pipeline can provide a sustainable revenue growth bridge. |
REGN strengths
- →Dupixent is one of the fastest-growing large-molecule drugs globally with 10+ approved indications
- →Veloci-Suite antibody discovery platform provides ongoing pipeline generation advantage
- →Strong balance sheet with significant cash enabling pipeline investment and buybacks
BIIB strengths
- →Leqembi (lecanemab) is one of the first approved Alzheimer's disease-modifying treatments
- →Deep neuroscience expertise and relationships spanning 40+ years of MS drug development
- →Eisai partnership on Leqembi shares development costs and commercialization risk
Risks to watch — REGN
- →Eylea biosimilar competition creating headwinds for the legacy eye care franchise
- →Dupixent growth will eventually slow as market penetration matures in lead indications
- →High dependence on two products (Dupixent and Eylea) for the majority of revenue
Risks to watch — BIIB
- →Leqembi commercial uptake materially below initial projections due to payer and logistical hurdles
- →MS revenue base eroding from generic Tecfidera competition
- →Alzheimer's drug market may take years to scale, creating a prolonged revenue gap
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