INCY vs ABBV: Incyte vs AbbVie Stock Comparison: AI Score, Valuation, Performance and Upside
Incyte is a focused JAK inhibitor biotech with Jakafi and Opzelura as its primary revenue drivers and an oncology-heavy pipeline, while AbbVie is a large-cap diversified biopharma managing Humira's biosimilar transition with Skyrizi, Rinvoq, and Botox. AbbVie is the safer, more diversified biopharma; Incyte is the smaller focused JAK inhibitor bet.
INCY vs ABBV is a focused JAK inhibitor biotech versus a diversified large-cap biopharma successfully managing the world's largest drug franchise biosimilar transition — Incyte wins if Opzelura and oncology pipeline succeed; AbbVie wins if Skyrizi/Rinvoq fully offset Humira erosion.
ABBV holds the edge across 3 of 5 key metrics in this comparison. INCY leads on both 1-year return (+66.54%) and forward P/E quality (13.83x vs 15.23x for ABBV), a relatively favorable combination of momentum and valuation. On fundamentals, INCY is growing revenue faster (20.90%), while ABBV maintains the higher operating margin (32.16%) — a classic growth-versus-profitability split. Analyst consensus implies meaningfully more upside for ABBV (+5.99%) than for INCY (-4.50%).
- →want focused JAK inhibitor exposure with Opzelura growth in atopic dermatitis
- →value Jakafi's standard-of-care position in myelofibrosis as a durable revenue base
- →prefer a smaller, more focused biotech with clear near-term growth drivers
- →are comfortable with binary pipeline clinical risk from oncology candidates
- →prefer a large-cap biopharma with diversified revenue across immunology, aesthetics, and oncology
- →value the Skyrizi and Rinvoq growth trajectory that is offsetting Humira biosimilar erosion
- →want dividend income from a profitable pharmaceutical company with durable cash flows
- →are comfortable with Humira biosimilar pressure as an already-known headwind with declining impact
| Metric | INCY | ABBV |
|---|---|---|
| AI score | 41.5 | 52.9 |
| AI rank | #1018 | #348 |
| Latest close | $114.23 | $248.00 |
| 1M return | +5.25% | +8.90% |
| 6M return | +6.89% | +12.69% |
| 1Y return | +66.54% | +28.86% |
How much would $10,000 be worth today if invested at the start of each period, with all dividends reinvested?
| Period | INCY | ABBV |
|---|---|---|
| 1Y ago | $16.32K (+63.2%) started 2025-07-14 | $12.95K (+29.5%) started 2025-07-14 |
| 5Y ago | $14.3K (+43.0%) started 2021-07-14 | $28.88K (+188.8%) started 2021-07-14 |
| 10Y ago | $13.91K (+39.1%) started 2016-07-14 | $88.35K (+783.5%) started 2016-07-14 |
Hypothetical — past performance does not guarantee future results.
| Metric | INCY | ABBV |
|---|---|---|
| Market cap | $23.32B | $438.31B |
| Trailing P/E | 16.48 | 122.21 |
| Forward P/E | 13.83 | 15.23 |
| Price/Sales | N/A | 5.85 |
| EV/Revenue | 3.61 | 7.99 |
| Analyst target | $111.45 | $262.93 |
| Target upside | -4.50% | +5.99% |
| Metric | INCY | ABBV |
|---|---|---|
| Revenue growth | 20.90% | 12.40% |
| Earnings growth | 83.80% | -46.20% |
| EPS growth | +83.80% | -46.20% |
| FCF margin | +10.42% | +33.13% |
| Operating margin | 25.55% | 32.16% |
| Profit margin | 26.71% | 5.79% |
| ROIC proxy | 30.82% | 6225.00% |
| Return on equity | 30.82% | 6225.00% |
| Dividend yield | N/A | 2.79% |
| Beta | 0.76 | 0.28 |
| Debt/equity | 0.70 | 4789.60 |
| Current ratio | 3.68 | 0.80 |
| Quick ratio | 3.40 | 0.52 |
Lower drawdown and smaller single-period drops generally indicate a smoother ride, though they do not guarantee lower future risk.
| Period | Metric | INCY | ABBV |
|---|---|---|---|
| 1Y | Growth | +63.23% | +29.49% |
| CAGR | +63.57% | +29.63% | |
| Sharpe ratio | 1.50 | 0.96 | |
| Max drawdown | 18.33% | 19.23% | |
| Max daily drop | 8.24% | 5.20% | |
| Max wkly drop | 8.91% | 8.49% | |
| 5Y | Growth | +43.02% | +144.13% |
| CAGR | +7.42% | +19.55% | |
| Sharpe ratio | 0.24 | 0.69 | |
| Max drawdown | 40.50% | 21.92% | |
| Max daily drop | 8.62% | 12.57% | |
| Max wkly drop | 12.82% | 17.30% | |
| 10Y | Growth | +39.07% | +465.08% |
| CAGR | +3.35% | +18.91% | |
| Sharpe ratio | 0.14 | 0.63 | |
| Max drawdown | 66.47% | 45.09% | |
| Max daily drop | 22.93% | 16.25% | |
| Max wkly drop | 23.17% | 19.39% |
| Category | INCY | ABBV |
|---|---|---|
| Company | Incyte Corporation | AbbVie Inc. |
| Sector | Healthcare | Healthcare |
| Industry | N/A | Drug Manufacturers - General |
| Core business | Biopharmaceutical company specializing in JAK inhibitor drugs, with Jakafi (ruxolitinib) for myelofibrosis and polycythemia vera, and Opzelura (ruxolitinib cream) for atopic dermatitis. Incyte's pipeline focuses on oncology and inflammatory diseases. | Diversified biopharmaceutical company with Skyrizi and Rinvoq (immunology), Humira (biosimilar competition began 2023), Botox (Allergan acquisition), and oncology. AbbVie has successfully pivoted from Humira dependence to Skyrizi/Rinvoq growth. |
| Investor focus | Opzelura (ruxolitinib cream) growth for atopic dermatitis, Jakafi lifecycle management, oncology pipeline advancement, and pipeline success in solid tumors. | Skyrizi and Rinvoq combined peak revenue potential, Humira biosimilar erosion pace, Botox and aesthetics durability, and pipeline advancement in neuroscience and oncology. |
- →Jakafi is the standard of care for myelofibrosis with minimal near-term generic competition
- →Opzelura's topical JAK inhibitor penetration in atopic dermatitis is growing rapidly as an alternative to systemic biologics
- →Strong balance sheet with no debt provides flexibility for business development and R&D investment
- →Skyrizi and Rinvoq combined are growing faster than Humira's biosimilar erosion, validating AbbVie's immunology transition
- →Allergan Aesthetics (Botox, Juvederm, CoolSculpting) provides diversified revenue in the aesthetics market
- →Deep immunology franchise expertise creates a durable platform for future drug development
- →Opzelura faces competition from Pfizer's Cibinqo (JAK inhibitor cream) and other topical treatments for atopic dermatitis
- →Jakafi patent expiration creates long-term biosimilar headwind that Incyte must offset with pipeline success
- →Binary clinical read-out risk from oncology pipeline candidates
- →Skyrizi and Rinvoq pricing pressure if biosimilar competition develops in IL-23 and JAK inhibitor markets
- →Humira biosimilar erosion, while partly offset by Skyrizi/Rinvoq, still weighs on net revenue
- →Neuroscience pipeline (psychiatric drugs) has a binary risk profile as trials proceed
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