CRSP vs EDIT Stock Comparison: AI Score, Valuation, Performance and Upside
CRSP is the clear leader in the CRISPR gene editing space having achieved the first-ever CRISPR therapy approval (Casgevy) with Vertex Pharmaceuticals, while EDIT is an earlier-stage gene editing company with clinical programs still working toward proving its approach. Both face the broader challenges of gene therapy commercialization, but CRSP has a meaningful head start.
CRSP vs EDIT compares the leading CRISPR gene editing company with a commercially approved therapy against an earlier-stage CRISPR competitor still advancing programs through clinical development.
EDIT holds the edge across 4 of 5 key metrics in this comparison. EDIT leads on both 1-year return (-8.27%) and forward P/E quality (-4.04x vs -16.10x for CRSP), a relatively favorable combination of momentum and valuation. On fundamentals, CRSP is growing revenue faster (1041.40%), while EDIT maintains the higher operating margin (-167.31%) — a classic growth-versus-profitability split. Analyst consensus implies meaningfully more upside for EDIT (+97.04%) than for CRSP (+55.54%).
Human Wall Street analysts' price targets, typically implying a ~12-month view — a separate signal from this site's own AI Prediction Signal further down the page, which is a 5-/30-day machine-learning forecast based on price history alone.
- Want exposure to the gene editing company that achieved the first CRISPR therapy approval
- Value the Vertex partnership for financial backing and commercial infrastructure
- Believe CRISPR-based cures will build into meaningful commercial franchises
- Want earlier-stage exposure to in vivo CRISPR gene editing technology
- See potential value in Editas's foundational IP and clinical programs at a smaller valuation
- Are comfortable with higher clinical and execution risk in exchange for earlier-stage upside
| Metric | CRSP | EDIT |
|---|---|---|
| AI scorei | 49.9 | 26.5 |
| AI ranki | #539 | #2482 |
| Latest closei | $48.56 | $2.55 |
| 1M returni | -10.07% | -6.59% |
| 3M returni | -5.96% | -12.07% |
| 6M returni | -7.36% | -15.84% |
| 1Y returni | -14.79% | -8.27% |
How much would $10,000 be worth today if invested at the start of each period, with all dividends reinvested?
| Period | CRSP | EDIT |
|---|---|---|
| 1Y ago | $8.52K (-14.8%) started 2025-11-05 | $9.17K (-8.3%) started 2025-11-05 |
| 5Y ago | $5.16K (-48.4%) started 2021-11-08 | $628.54 (-93.7%) started 2021-11-08 |
| 10Y ago | $31.93K (+219.3%) started 2016-11-07 | $1.89K (-81.1%) started 2016-11-07 |
Hypothetical — past performance does not guarantee future results.
| Metric | CRSP | EDIT |
|---|---|---|
| Market capi | $5.44B | $467.65M |
| Trailing P/Ei | N/A | N/A |
| Forward P/Ei | -16.10 | -4.04 |
| Price/Salesi | N/A | N/A |
| EV/Revenuei | 292.23 | 5.86 |
| Analyst targeti | $87.56 | $6.00 |
| Target upsidei | +55.54% | +97.04% |
| Metric | CRSP | EDIT |
|---|---|---|
| Revenue growthi | 1041.40% | 232.30% |
| Earnings growthi | N/A | N/A |
| EPS growthi | N/A | N/A |
| FCF margini | -1611.75% | -94.28% |
| Operating margini | -1127.55% | -167.31% |
| Profit margini | 0.00% | -157.32% |
| ROIC proxyi | -26.10% | -118.82% |
| Return on equityi | -26.10% | -118.82% |
| Dividend yieldi | N/A | N/A |
| Payout ratioi | 0.00% | N/A |
| Dividend growth streaki | N/A | N/A |
| Betai | 1.74 | 2.06 |
| Debt/equityi | 44.87 | 14.73 |
| Current ratioi | 17.85 | 3.19 |
| Quick ratioi | 17.79 | 3.13 |
Over the past year, CRSP and EDIT have moved moderately in the same direction (correlation of 0.63), based on daily returns.
Lower drawdown and smaller single-period drops generally indicate a smoother ride, though they do not guarantee lower future risk.
| Period | Metric | CRSP | EDIT |
|---|---|---|---|
| 1Y | Growthi | -14.79% | -8.27% |
| CAGRi | -14.80% | -8.28% | |
| Volatilityi | 57.19% | 82.19% | |
| Sharpe ratioi | -0.08 | 0.25 | |
| Sortino ratioi | -0.11 | 0.37 | |
| Max drawdowni | 28.18% | 40.11% | |
| Current drawdowni | 21.54% | 32.00% | |
| Avg drawdowni | 12.48% | 20.21% | |
| Ulcer Indexi | 14.20% | 22.50% | |
| Max daily dropi | 11.59% | 15.57% | |
| Max wkly dropi | 18.19% | 22.13% | |
| 5Y | Growthi | -48.42% | -93.71% |
| CAGRi | -12.42% | -42.56% | |
| Volatilityi | 61.03% | 93.62% | |
| Sharpe ratioi | 0.01 | -0.20 | |
| Sortino ratioi | 0.01 | -0.32 | |
| Max drawdowni | 66.78% | 97.58% | |
| Current drawdowni | 48.42% | 93.71% | |
| Avg drawdowni | 40.85% | 81.34% | |
| Ulcer Indexi | 42.39% | 82.96% | |
| Max daily dropi | 13.32% | 35.63% | |
| Max wkly dropi | 21.49% | 42.50% | |
| 10Y | Growthi | +219.26% | -81.05% |
| CAGRi | +12.32% | -15.34% | |
| Volatilityi | 63.76% | 84.28% | |
| Sharpe ratioi | 0.43 | 0.15 | |
| Sortino ratioi | 0.66 | 0.24 | |
| Max drawdowni | 85.11% | 98.92% | |
| Current drawdowni | 76.88% | 97.18% | |
| Avg drawdowni | 50.46% | 62.17% | |
| Ulcer Indexi | 56.83% | 69.95% | |
| Max daily dropi | 17.10% | 35.63% | |
| Max wkly dropi | 30.47% | 42.50% |
| Category | CRSP | EDIT |
|---|---|---|
| Company | CRISPR Therapeutics AG | Editas Medicine, Inc. |
| Sector | Healthcare | Healthcare |
| Industry | Biotechnology | Biotechnology |
| Core business | CRISPR Therapeutics uses CRISPR-Cas9 gene editing to develop transformative medicines, led by Casgevy (exa-cel), the first CRISPR-based therapy approved by the FDA — for sickle cell disease and beta-thalassemia — developed in partnership with Vertex Pharmaceuticals. | Editas Medicine is a clinical-stage gene editing company using CRISPR-Cas9 and other gene editing tools to develop medicines, with early programs in eye disease (Leber congenital amaurosis) and hematological conditions. |
| Investor focus | Investors track Casgevy's commercial launch and patient uptake, the next wave of in vivo CRISPR programs (particularly cardiovascular), and the overall expansion of the gene editing therapy pipeline. | Investors track Editas's clinical pipeline advancement, particularly its in vivo eye disease programs, and the company's strategic focus following earlier setbacks and pipeline restructuring. |
- First company to achieve FDA approval for a CRISPR-based therapy (Casgevy for sickle cell disease and beta-thalassemia)
- Partnership with Vertex Pharmaceuticals provides commercial infrastructure and significant financial backing
- Strong cash position from Vertex partnership funding enables substantial R&D investment
- Early-mover in CRISPR gene editing with foundational IP positions
- In vivo gene editing approach (delivering CRISPR directly into the body) could be simpler to administer than ex vivo approaches if successful
- Eye disease programs provide early clinical proof-of-concept opportunities
- Casgevy's commercial uptake has been limited by complex manufacturing, treatment requirements (patient conditioning), and high price — adoption is slower than initially hoped
- Ex vivo gene editing approach requires complex bone marrow transplantation-like procedures that limit eligible patient numbers
- Competition from other gene therapies including Bluebird Bio's Lyfgenia
- No commercially approved therapies yet; all programs are pre-commercial
- Has faced clinical and operational setbacks that required pipeline restructuring
- Significantly smaller than CRISPR Therapeutics in both resources and clinical advancement
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