RGEN vs ALNY Stock Comparison: AI Score, Valuation, Performance and Upside
Repligen and Alnylam Pharmaceuticals both serve the broader biotechnology industry but from very different angles: Repligen supplies bioprocessing tools and consumables used to manufacture biologic drugs, while Alnylam develops its own RNA interference therapeutics targeting specific rare genetic and other diseases.
Repligen offers indirect, picks-and-shovels exposure to broad biopharmaceutical industry growth without single-drug risk, while Alnylam offers a more direct, platform-based bet on RNA interference therapeutics gaining commercial and pipeline traction. Consider whether you prefer Repligen's diversified tools exposure or Alnylam's concentrated therapeutic platform bet.
ALNY holds the edge across 4 of 5 key metrics in this comparison. RGEN has delivered stronger 1-year price return (+44.26% vs -40.52%), though ALNY has the better forward P/E setup (19.55x vs 65.57x for RGEN). ALNY leads on both revenue growth (66.90%) and operating margin (17.93%), suggesting a stronger fundamental setup on both dimensions. Analyst consensus implies meaningfully more upside for ALNY (+50.42%) than for RGEN (+8.53%).
Human Wall Street analysts' price targets, typically implying a ~12-month view — a separate signal from this site's own AI Prediction Signal further down the page, which is a 5-/30-day machine-learning forecast based on price history alone.
- Want indirect, picks-and-shovels exposure to broad biopharmaceutical industry growth
- Value a diversified customer base reducing dependence on any single drug's success
- Believe bioprocessing order recovery following post-pandemic destocking offers upside
- Prefer a recurring consumables revenue model over concentrated therapeutic development risk
- Want direct exposure to a pioneering RNA interference drug technology platform
- Believe an expanding portfolio of approved therapies validates the platform's commercial potential
- Are comfortable with pipeline execution risk tied to a relatively newer drug technology
- See value in a growing pipeline leveraging the same core technology across multiple disease areas
| Metric | RGEN | ALNY |
|---|---|---|
| AI scorei | 47.8 | 52.4 |
| AI ranki | #574 | #316 |
| Latest closei | $167.60 | $266.11 |
| 1M returni | +5.68% | +16.35% |
| 6M returni | +34.05% | -16.97% |
| 1Y returni | +44.26% | -40.52% |
How much would $10,000 be worth today if invested at the start of each period, with all dividends reinvested?
| Period | RGEN | ALNY |
|---|---|---|
| 1Y ago | $13.9K (+39.0%) started 2025-09-04 | $5.87K (-41.3%) started 2025-09-04 |
| 5Y ago | $5.66K (-43.4%) started 2021-09-07 | $14.13K (+41.3%) started 2021-09-07 |
| 10Y ago | $53.02K (+430.2%) started 2016-09-06 | $37.28K (+272.8%) started 2016-09-06 |
Hypothetical — past performance does not guarantee future results.
| Metric | RGEN | ALNY |
|---|---|---|
| Market capi | $9.76B | $32.93B |
| Trailing P/Ei | 236.90 | 42.95 |
| Forward P/Ei | 65.57 | 19.55 |
| Price/Salesi | N/A | N/A |
| EV/Revenuei | 12.28 | 6.79 |
| Analyst targeti | $187.70 | $370.20 |
| Target upsidei | +8.53% | +50.42% |
| Metric | RGEN | ALNY |
|---|---|---|
| Revenue growthi | 11.90% | 66.90% |
| Earnings growthi | -65.90% | N/A |
| EPS growthi | -65.90% | N/A |
| FCF margini | +14.45% | +5.65% |
| Operating margini | 9.31% | 17.93% |
| Profit margini | 5.29% | 16.13% |
| ROIC proxyi | 1.99% | 96.56% |
| Return on equityi | 1.99% | 96.56% |
| Dividend yieldi | N/A | N/A |
| Betai | 1.01 | 0.28 |
| Debt/equityi | 32.72 | 220.62 |
| Current ratioi | 9.05 | 3.06 |
| Quick ratioi | 7.30 | 2.79 |
Over the past year, RGEN and ALNY have moved weakly in the same direction (correlation of 0.16), based on daily returns.
Lower drawdown and smaller single-period drops generally indicate a smoother ride, though they do not guarantee lower future risk.
| Period | Metric | RGEN | ALNY |
|---|---|---|---|
| 1Y | Growthi | +38.99% | -41.33% |
| CAGRi | +39.06% | -41.37% | |
| Volatilityi | 46.14% | 46.96% | |
| Sharpe ratioi | 0.85 | -0.98 | |
| Sortino ratioi | 1.31 | -1.17 | |
| Max drawdowni | 40.28% | 58.17% | |
| Current drawdowni | 7.93% | 45.83% | |
| Avg drawdowni | 14.96% | 28.47% | |
| Ulcer Indexi | 19.22% | 32.69% | |
| Max daily dropi | 8.31% | 28.31% | |
| Max wkly dropi | 18.23% | 24.38% | |
| 5Y | Growthi | -43.40% | +41.34% |
| CAGRi | -10.78% | +7.18% | |
| Volatilityi | 51.10% | 50.86% | |
| Sharpe ratioi | -0.06 | 0.29 | |
| Sortino ratioi | -0.08 | 0.47 | |
| Max drawdowni | 68.27% | 58.17% | |
| Current drawdowni | 48.31% | 45.83% | |
| Avg drawdowni | 48.68% | 19.86% | |
| Ulcer Indexi | 50.24% | 24.09% | |
| Max daily dropi | 13.22% | 28.31% | |
| Max wkly dropi | 21.92% | 24.38% | |
| 10Y | Growthi | +430.21% | +272.76% |
| CAGRi | +18.17% | +14.07% | |
| Volatilityi | 46.10% | 54.30% | |
| Sharpe ratioi | 0.49 | 0.43 | |
| Sortino ratioi | 0.73 | 0.66 | |
| Max drawdowni | 68.27% | 59.78% | |
| Current drawdowni | 48.31% | 45.83% | |
| Avg drawdowni | 28.94% | 22.74% | |
| Ulcer Indexi | 36.52% | 27.62% | |
| Max daily dropi | 14.44% | 48.49% | |
| Max wkly dropi | 21.97% | 49.44% |
| Category | RGEN | ALNY |
|---|---|---|
| Company | Repligen Corporation | Alnylam Pharmaceuticals, Inc. |
| Sector | Healthcare | Healthcare |
| Industry | Medical Instruments & Supplies | Biotechnology |
| Core business | A life sciences company that develops and manufactures bioprocessing technologies and consumables used by biopharmaceutical companies to produce biologic drugs, positioning it as a picks-and-shovels supplier to the broader biotech industry. | A biotechnology company pioneering RNA interference therapeutics, a drug technology that silences disease-causing genes, with an expanding portfolio of approved and pipeline therapies addressing rare genetic and other diseases. |
| Investor focus | Bioprocessing equipment and consumables order recovery following a post-pandemic industry destocking cycle, new product adoption trends, and overall biopharmaceutical manufacturing capacity investment levels. | Commercial growth of approved RNA interference therapies, pipeline progress across new disease areas, and overall validation of RNA interference as a durable drug development platform. |
- Picks-and-shovels bioprocessing technology position provides indirect exposure to broad biopharmaceutical industry growth without single-drug risk
- Diversified customer base across many biopharmaceutical manufacturers reduces dependence on any single drug's commercial success
- Recurring consumables revenue model provides more stable, repeatable demand than one-time equipment sales alone
- Pioneering position in RNA interference therapeutics provides a differentiated, platform-based approach to drug development
- Expanding portfolio of approved therapies demonstrates successful translation of the RNA interference platform into commercial products
- Growing pipeline across multiple disease areas leverages the same core technology platform for diversified growth
- Bioprocessing demand has been affected by post-pandemic destocking cycles as customers worked down excess inventory
- Revenue growth is tied to broader biopharmaceutical manufacturing capacity investment, which can slow during industry funding downturns
- Faces competition from other life sciences tools and bioprocessing equipment suppliers
- RNA interference remains a relatively newer drug technology platform with less long-term commercial track record than traditional biologics
- Pipeline execution risk is elevated given the number of programs relying on continued platform technology validation
- Faces competition from other gene-silencing and RNA-based therapeutic approaches being developed by rival companies
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